Mesobotox: A Gentle Touch for Lasting Beauty
- Dr Vera
- Nov 23, 2023
- 5 min read
Updated: 1 day ago

What is Mesobotox?
Mesobotox represents an innovative evolution in aesthetic medicine, employing multiple microdroplets of botulinum toxin (BoNT) at lower concentrations. Unlike traditional Botox treatments that target muscles directly, Mesobotox utilizes a specialized injection technique targeting the superficial muscle fibers and dermal layer of the skin.
The primary objective of this treatment is to achieve the relaxation of fine lines and rhytide (early manifestations of wrinkles), all without the undesired outcome of a "frozen" or "plastic" appearance. In addition to its effectiveness in facial rejuvenation, this technique has found utility in addressing concerns such as hyperhidrosis, seborrhoea, and keloids. Typically, it is administered through mesotherapy, a specialized injection technique targeting the superficial muscle fibers of the skin.
Distinguishing Botox from Mesobotox
Traditional Botox is administered deep into the muscle fibers attached to facial bones, resulting in muscle relaxation and, consequently, the reduction of dynamic wrinkles' severity. Conversely, Mesobotox works by inhibiting the "pulling" effects of superficial muscle fibers on the skin, while preserving the function of the deeper muscle fibers, thereby imparting a refreshed appearance to the face.
Factor | Traditional Botox | Mesobotox |
Injection Depth | Deep into muscle fibers attached to facial bones | Intradermal/superficial muscle fibers of the skin |
Concentration | Higher concentration in specific points | Lower concentration in multiple microdroplets |
Number of Injections | Fewer, targeted injections | Multiple injections (often 100-500) across treatment area |
Effect on Muscles | Complete muscle relaxation | Inhibits “pulling” effects while preserving deeper muscle function |
Primary Target | Dynamic wrinkles caused by muscle contraction | Skin texture, pore size, and fine lines |
Appearance | May create a more static look | More natural, refreshed appearance |
Best For | Deep dynamic wrinkles | Fine lines, early signs of aging, and skin quality concerns |
Did you know? Not everyone is an ideal candidate for Mesobotox or other botox treatment. Want to find out if it’s right for you? Check out this article!

Application of Mesobotox for Facelift
Facial aging is characterized by an imbalance between the levator (lifting) and depressor (sagging) muscles involved in facial expressions, compounded by the relentless force of gravity, leading to facial drooping and sagging when depressor muscles predominate. Mesobotox is instrumental in rebalancing these muscles, weakening the downward pull exerted by the depressors and allowing the levators (opposing muscles) to elevate the skin. Its superficial injection approach makes it a favored method, especially in periorbital rejuvenation (Iranmanesh, B. et al., 2022).

The Nefertiti Lift, often referred to when redefining facial and neck contours, draws its name from the ancient Egyptian Queen Nefertiti, renowned for her long and graceful neck. This technique involves Mesobotox injections into the platysma and its posterior band to counteract the depressor effect on the cheeks. However, it may not be suitable for individuals with greater skin laxity and less pronounced posterior bands.
Mesobotox is most indicated when early signs of aging in the lower face and neck do not warrant the invasiveness and extent of surgical facelift procedures (Wanitphakdeedecha, R. et al.,2020). It can be effectively combined with other skin-tightening devices and therapies.
The toxins used in Mesobotox are no different from traditional Botox, resulting in typical results lasting approximately 4 to 6 months. This translates to 2 to 3 repeated sessions per year for maintenance.

Potential Side Effects of Mesobotox
Mesobotox appears to have minimal observable side effects, with the primary exception being individual variations in pain sensitivity. Interestingly, when administered to the forehead area, the Mesobotox technique typically causes less discomfort than traditional methods. Additionally, its superficial injection level tends to result in less bruising compared to conventional Botox treatments. Some transient side effects reported in the literature include a slight feeling of stiffness in the forehead area and mild weakness in the periorbital muscles.

“Did you know that Mesotox can also be beneficial for acne and oil control?”
Botulinum toxin (BoNT) is known to reduce sebaceous gland activity, thereby improving seborrhea and minimizing pore size (Kaur, I., 2022). It has also been proposed as a maintenance treatment for acne-prone skin. Mesobotox, in particular, provides even coverage across the skin, helping to prevent compensatory sebum production in untreated areas.
Wondering what other solutions or treatments besides Mesobotox are available to reduce necklines and wrinkles that reveal your age? We’ve prepared a comprehensive article covering all the treatments for neckline just for you!
Why Choose Dream Clinic’s Mesobotox Treatment?
At Dream Clinic, we prioritize your aesthetic goals with personalized care and expertise:
Advanced Technique Mastery: Our specialists have undergone extensive training in the precise Mesobotox technique, ensuring optimal distribution of microdroplets at the correct depth.
Customized Treatment Protocols: We recognize that each face is unique, tailoring our approach to your specific skin concerns and desired outcomes.
Premium Products: We use only the highest quality botulinum toxin products, ensuring safety and effectiveness with every treatment.
Comprehensive Approach: Our specialists may recommend complementary treatments to enhance your results, providing a holistic rejuvenation strategy.
Natural-Looking Results: We prioritize subtle enhancement that preserves your natural expressions while improving skin quality and reducing fine lines.
Continued Support: From your initial consultation through follow-up care, our team remains committed to your satisfaction and results.
Our Mesobotox treatments are designed to provide subtle, natural-looking rejuvenation that enhances your natural beauty without obvious signs of intervention.
The "Radiant Glow"
Mesobotox represents an evolution in aesthetic medicine, offering a more nuanced approach to facial rejuvenation. By understanding the balance between effective treatment and natural appearance, this innovative technique provides lasting beauty with a gentle touch.
Whether you’re looking to address fine lines, improve skin texture, reduce facial redness, or manage oily, acne-prone skin, Mesobotox offers versatile solutions with minimal downtime and natural-looking results.
Ready to explore how Mesobotox can enhance your natural beauty? Schedule a consultation with our experienced Aesthetic Specialists at Dream Clinic today to begin your journey toward refreshed, radiant skin. As one of the leading Skin Clinics in KL and Penang, we’re committed to helping you achieve your aesthetic goals with expert care and personalized attention.

References
Iranmanesh, B., Khalili, M., Mohammadi, S., Amiri, R., & Aflatoonian, M. (2022). Employing Microbotox technique for facial rejuvenation and face‐lift. Journal of Cosmetic Dermatology, 21(10), 4160–4170. https://doi.org/10.1111/jocd.14768
Kaur, I., Kandhari, R., Gupta, J., & Al-Niaimi, F. (2022). Microdroplet Botulinum toxin: A Review. Journal of Cutaneous and Aesthetic Surgery, 15(2), 101. https://doi.org/10.4103/jcas.jcas_162_21
Seo, K. K. (2005). Clinical tips and recent advances in cosmetic uses of botulinum toxin including Mesobotox. Journal of the Korean Medical Association, 48(12), 1225. https://doi.org/10.5124/jkma.2005.48.12.1225
Wanitphakdeedecha, R., Nokdhes, Y., Patthamalai, P., Yan, C., Techapichetvanich, T., Phothong, W., Eimpunth, S., & Manuskiatti, W. (2020). Intradermal injection of incobotulinumtoxina for face lifting. Dermatologic Therapy, 33(6). https://doi.org/10.1111/dth.13944