Biostimulator Brands Compared: Why Radiesse Stands Out from The Rest?

Dr. Vera Teh
Mar 7
7 min read

Updated: Jun 16

In the growing landscape of non-surgical aesthetic treatments, injectable biostimulators such as Dermal Filler Malaysia that offer long-term skin rejuvenation by stimulating natural collagen production are becoming increasingly popular. With a variety of options on the market, choosing the right one can feel overwhelming.

In this article, we’ll evaluate and compare the five leading biostimulator brands available in Malaysia, including Radiesse, Sculptra, Ellansé, Juvelook, and Aesthefill. While each offers unique benefits, Radiesse consistently stands out for its combination of lifting power, collagen stimulation, and longevity. Let’s see what sets it apart.

What Is a Biostimulator?

Biostimulators are advanced injectable dermal fillers that rejuvenate the skin by stimulating natural collagen production in your body. Unlike traditional dermal fillers that simply add volume, biostimulators work beneath the surface to boost collagen synthesis, leading to long-lasting improvements in skin texture, elasticity, and overall appearance.

By promoting collagen production, these treatments offer a more natural and gradual enhancement, making them a popular choice for those seeking subtle yet significant results.

How Does Biostimulator Work?

As we age, our body's natural collagen production declines, leading to wrinkles, sagging skin, and noticeable loss of volume. Biostimulators offer a longer-lasting and regenerative solution by:

Activating fibroblasts to stimulate natural collagen production.
Rebuilding the extracellular matrix (ECM) improves skin structure and elasticity.
Delivering gradual, natural-looking results that can last 12 months or more, with continued skin improvement over time.

Unlike hyaluronic acid-based fillers that simply “fill,” biostimulators rebuild from within, making them a powerful anti-aging tool for long-term rejuvenation.

Top Biostimulator Brands Available in Malaysia

The leading biostimulator brands available in Malaysia’s skin clinics include Radiesse, Sculptra, Ellansé, Juvelook, and Aesthefill, each offering unique benefits tailored to different needs and aging concerns.

Radiesse

Radiesse is widely recognised for delivering both instant aesthetic enhancement including double chin treatment and long-term skin rejuvenation. It’s a preferred choice for individuals who want visible lift and structural support in one treatment.

Sculptra

Sculptra is ideal for those who prefer gradual and natural-looking skin rejuvenation. It’s particularly popular among individuals who want to focus on long-term collagen rebuilding instead of an immediate boost.

Ellansé

Ellansé appeals to those who want personalised results with flexibility in how long the effects last. It’s often chosen for its ability to address both aging signs and individual treatment preferences.

Juvelook

Juvelook is preferred by younger patients or those new to biostimulators. It offers a gentle skin-refreshing effect that combines subtle collagen stimulation with a hydrated and radiant finish.

Aesthefill

Aesthefill stands out for its slow and steady skin regeneration. It’s suitable for patients looking for a progressive anti-aging solution that enhances firmness and skin quality over time.

Designed by Dr. Vera

Looking for a more immediate enhancement? Explore Juvederm Malaysia, the trusted traditional dermal filler offered at Dream Clinic, perfect for those seeking smoother skin without collagen stimulation.

Biostimulator Brands Comparison

Biostimulators vary in composition, longevity, and results. The table below offers a side-by-side comparison of top biostimulator brands at a glance:

Table by Dr. Vera

Brands	Main Ingredient	Longevity	Sessions required	Mechanism
Radiesse	Calcium Hydroxylapatite (CaHA)	12 - 18 months	1 - 2 sessions	Immediate volume + collagen stimulation
Sculptra	Poly-L-lactic acid (PLLA)	18 - 24 months	3 - 4 sessions	Gradual collagen stimulation (no immediate volume)
Ellansé	Polycaprolactone (PCL)	18 - 24 months	Varies by subtype	Collagen stimulation + customizable longevity
Juvelook	Polylactic Acid (PLA) + Hyaluronic Acid (HA)	12 - 18 months	3 - 5 sessions	Gentle collagen stimulation + hydration
AestheFill	Poly-D, L-lactic acid (PDLLA)	18 - 24 months	3 - 4 sessions	Gradual collagen regeneration via fibroblast activation

What Makes Radiesse Stand Out?

Among the biostimulator brands available today, Radiesse sets itself apart with a powerful combination of immediate results, long-term skin rejuvenation, and clinical credibility. Let’s explore why it remains a top choice among competitors.

Immediate Visible Results

Delivers results the fastest due to its instant volumizing effect from the Calcium Hydroxylapatite (CaHA) gel carrier. It provides immediate volume restoration while simultaneously stimulating long-term collagen production for skin regeneration.

High Safety Profile and FDA Approval

Radiesse and Sculptra are both FDA-approved, while Ellansé, Juvelook, and Aesthefill are not FDA-approved and are primarily used in Europe or Asia. Radiesse also has a proven track record since 2006, backed by over a decade of clinical use and safety data.

Fewer Sessions Required

It typically requires just 1 to 2 sessions, making it more cost-effective and time-efficient compared to other brands that often require 3 or more sessions to achieve optimal results.

Dual Benefit

Provides skin elasticity and firmness beyond volume. Its unique composition of Calcium Hydroxylapatite (CaHA) provides not only immediate volume but also stimulates collagen production over time.

Versatile Aesthetic Solution

Radiesse stands out not only for its results and efficiency but also for its multi-purpose applications, making it suitable for a wide range of aesthetic needs. Here’s how you can use Radiesse:

As a Filler: Instantly restores volume to sagging or hollow areas of the face.
As a Biostimulator: Encourages collagen production, improving skin texture and elasticity.
As a Vertical Lifting Tool: Provides a subtle lift to facial contours.
As a Volumizer: Enhances facial features by adding volume to areas like cheeks and jawline.

Retrieved from: https://www.merzaesthetics.nl/radiesse-campaign/en

Looking for an injectable treatment to achieve firmer, more toned skin? Dream Clinic now offers Plinest, a treatment that promotes skin healing and rejuvenation, helping reduce signs of aging and damage.

How Radiesse Works?

Radiesse is uniquely formulated with calcium hydroxylapatite (CaHA) microspheres suspended in a carboxymethylcellulose (CMC) gel. This dual-action composition delivers both immediate and long-term skin rejuvenation.

The CMC gel provides instant volume and lift, enhancing facial contours right after injection. Meanwhile, the CaHA microspheres integrate into the skin, stabilizing the extracellular matrix (ECM), supporting fibroblast activity, and stimulating natural collagen production.

Over time, it promotes neocollagenesis, which replaces weaker type III collagen with stronger type I collagen for firmer skin. Its biocompatible formula also reduces the risk of granuloma formation, making it safer than many synthetic polymer-based biostimulators.

Who Should Choose Radiesse?

Each biostimulator brand is designed to meet different needs, so the key is to find the one that best suits your personal goals and skin concerns. If you're considering Radiesse, here's who it's most ideal for:

Individuals with moderate to severe facial wrinkles and folds. Radiesse is ideal for deep lines like nasolabial folds and marionette lines, helping to smooth and refresh aging skin.

Those looking to enhance facial contours or restore lost volume. Perfect for hollow cheeks, sunken temples, or a sagging jawline, Radiesse restores volume and definition.

Anyone seeking non-surgical hand rejuvenation. One of the few fillers approved for hands, it reduces wrinkles and visible veins for a more youthful appearance.

People prefer long-lasting and layered results. Radiesse delivers instant volume and stimulates collagen for results that improve over time and last over a year.

Combining Radiesse with Other Treatments

Radiesse pairs well with a variety of other aesthetic treatments, from hydrators and Botox to energy-based devices to deliver comprehensive facial rejuvenation. Combining treatments not only enhances overall results but also allows you to target multiple concerns at once. Here are the suggested combination treatments:

Concerned about fine lines and wrinkles? Pair Botox with Radiesse to smooth dynamic wrinkles and restore volume, effectively turning back the clock by up to 10 years.
In your 20s or 30s and looking to prevent signs of aging? Consider combining Radiesse with skin hydrators like Profhilo, Rejuran Healer, Revok50, or Volite for subtle collagen stimulation and deep hydration.
Want firmer, more lifted skin? A combination of Radiesse and energy-based treatments such as HIFU, Oligio, or Fotona 4D for face liftring treatment Malaysia can help tighten and contour the skin for a more sculpted, youthful appearance.

By tailoring your treatment approach, you can achieve results that are both natural and long-lasting.

Let's discuss your aesthetic goals and create a personalized treatment plan. Contact Dream Clinic today and schedule a consultation with me, Dr. Vera. Let's make your skin's fairytale ending a reality!

References

Amiri, M. et al. (2024) ‘Calcium hydroxylapatite (CAHA) and aesthetic outcomes: A systematic review of controlled clinical trials’, Journal of Clinical Medicine, 13(6), p. 1686. doi:10.3390/jcm13061686.

Biostimulators and their mechanisms of action. Available at: https://docs.bvsalud.org/biblioref/2022/04/1363771/12_n2_771_en.pdf

Koren, A. et al. (2019) ‘Efficacy of a combination of diluted calcium hydroxylapatite‐based filler and an energy‐based device for the treatment of facial atrophic acne scars’, Clinical and Experimental Dermatology, 44(5). doi:10.1111/ced.13952.

Pavicic, T. (2013). Calcium hydroxylapatite filler: an overview of safety and tolerability. Journal of drugs in dermatology : JDD, 12 9, 996-1002 . Płatkowska, A. et al. (2023) ‘Combined bipolar radiofrequency and non-crosslinked hyaluronic acid mesotherapy protocol to improve skin appearance and epidermal barrier function: A pilot study’, Pharmaceuticals, 16(8), p. 1145. doi:10.3390/ph16081145.

FAQs

What are the top biostimulator brands available in Malaysia?

The leading biostimulator brands available in Malaysia include Radiesse, Sculptra, Ellansé, Juvelook, and Aesthefill. Each offers unique formulations and treatment outcomes designed to stimulate natural collagen production and improve skin quality over time.

Which biostimulator brand offers the fastest visible results?

Radiesse delivers the fastest visible results due to the formulation CMC gel, which provides immediate volume and lift upon injection. Unlike other brands that take weeks to show effects, Radiesse offers instant enhancement while also promoting long-term collagen production.

Which biostimulator brand is FDA-approved?

Radiesse and Sculptra are both FDA-approved for aesthetic use. In contrast, Ellansé, Juvelook, and Aesthefill are commonly used in Europe and Asia but are not FDA-approved at this time.

What’s the difference between Radiesse and Sculptra in terms of collagen stimulation?

While both stimulate collagen, Radiesse offers an immediate volumizing effect with visible lift and stimulates collagen synthesis over time. Sculptra works gradually and requires multiple sessions to build up collagen.

Are biostimulator brands better than traditional fillers?

Biostimulators like Radiesse provide a longer-lasting effect. They provide regenerative benefits by stimulating natural collagen, making them ideal for long-term skin rejuvenation. Traditional fillers like Juvederm Malaysia offer immediate but temporary volume and hydration, best suited for individuals seeking short-term results.