Using Polynucleotides to Treat the Body: A New Era in Regenerative Aesthetics

Saggy and wrinkly tummy

Walk into any modern aesthetic clinic, and you’ll hear words like “collagen stimulation,” “skin rejuvenation,” and “bio-repair.” But lately, there’s one new superstar quietly stealing the show—polynucleotides (PNs). No longer just a buzzword, polynucleotides are now a scientifically-backed tool in regenerative medicine, not only for the face but increasingly for the body.

So, what exactly are polynucleotides? Why are they getting so much attention? And more importantly, how are they changing the way we treat aging and damaged skin—not just on the face, but everywhere from necks to knees?

Let’s break it down in a way that makes sense whether you’re an aesthetic aficionado or just beginning your skin journey.

What Are Polynucleotides, Really?

Trout eggs & sperm

Polynucleotides are fragments of DNA derived mostly from salmon or trout sperm (yes, fish—but don’t freak out just yet). These molecules are highly purified and bio-compatible, which means your body happily welcomes them without launching a red-alert immune response.

When injected into the skin, polynucleotides act as biostimulators, meaning they don’t replace lost volume or fill wrinkles directly. Instead, they nudge your skin to heal, hydrate, and regenerate itself from within at cellular level. Imagine them as gentle coaches encouraging your fibroblasts—the skin’s hardworking cells—to produce collagen, elastin, and hyaluronic acid.

These are not new inventions, by the way. Polynucleotides have been studied in wound healing and ophthalmology for decades. But the aesthetic world is only now catching up, and we're seeing exciting results, especially for body concerns.

Why Use Polynucleotides on the Body?

Most of us pay close attention to our faces, but skin on the body is just as prone to aging, laxity, scarring, and dehydration—sometimes even more so due to sun exposure, hormonal changes, or weight fluctuations. Think of areas like:

• Loose or crepey skin on upper arms or inner thighs

• Stretch marks on the abdomen, hips, or buttocks

• Sun-damaged décolletage

• Skin laxity after liposuction or pregnancy

• Scars or post-inflammatory hyperpigmentation

  
  

  

  Stretch marks

Their regenerative and hydrating action makes them ideal for areas that are harder to treat with fillers or energy-based devices.

How Do Polynucleotides Work in the Skin?

Polynucleotides (PNs) are long chains of DNA fragments that act like a biological repair signal to the skin. When injected, they don't just sit there — they get to work by activating your skin's natural healing processes. Here's how:

 1. Stimulate Fibroblast Activity

Fibroblasts are the “builders” of the skin. They’re responsible for producing collagen, elastin, and hyaluronic acid — the essential ingredients for firmness, elasticity, and hydration.

Polynucleotides stimulate fibroblasts, increasing their activity and encouraging them to produce more structural proteins. This leads to:

• Smoother, firmer skin

• Increased dermal thickness

• Fewer fine lines and wrinkles

 2. Enhance Skin Hydration

Polynucleotides have a hydrophilic (water-loving) structure. This allows them to bind and retain water in the dermis, hydrating the skin from within. Think of them as mini water reservoirs that plump up dehydrated or crepey skin, especially in delicate areas like the neck, chest, or underarms.

 3. Promote Tissue Repair and Regeneration

PNs were originally used in wound healing — and for good reason. They:

• Improve cell turnover

• Encourage angiogenesis (formation of new blood vessels)

• Help damaged tissue regenerate

  
  

This makes them incredibly useful not just for aging skin, but also for treating scars, stretch marks, and post-procedure recovery.

 4. Reduce Inflammation and Oxidative Stress

Polynucleotides have anti-inflammatory and antioxidant properties. They help calm stressed or irritated skin, making them ideal for patients with:

• Sensitive skin

• Post-acne inflammation

• Rosacea-prone or sun-damaged skin

By neutralizing free radicals, they also slow down the breakdown of collagen caused by UV exposure or pollution.

Combining with Advanced Technology

At Dream Clinic, we often pair polynucleotide therapy with other evidence-based technologies to boost results:

• Biostimualtors or Radiesse – hyperdiluted Radiesse spreads smoothly and stimulates widespread collagen production. This improves skin thickness and smooths wrinkling.

• Microneedling or Sylfirm X RF – to enhance absorption and treat acne scars or stretch marks

• Fotona TightSculpting – for additional abdominal skin tightening and toning

• HA-based Skinboosters or Profhilo – for extra hydration and glow

• Laser treatments – for pigmentation and texture refinement

The goal is synergy — combining gentle regenerative stimulation with targeted technologies for visible, long-lasting outcomes.

What to Expect After Treatment

Most patients experience:

• Mild redness or swelling that subsides within 1–2 days

• Gradual but natural improvement over 4–6 weeks

• Better skin tone, texture, and firmness — especially in areas that are hard to treat with traditional methods

Because polynucleotides are non-crosslinked and bioidentical, they're very safe and well-tolerated, even for sensitive or thin skin.

Curious to Learn More?

What excites us most at Dream Clinic is that polynucleotides are not just a beauty trend — they’re part of a broader movement in regenerative aesthetics. As we shift from simply "fixing" aging signs to supporting the skin’s natural biology, treatments like polynucleotides are leading the charge.

Whether you’re looking to smooth out crepey skin, fade scars, or just give your body a regenerative boost, this treatment is a natural, effective option worth considering. Come visit us at Dream Clinic, talk to me Dr. Eunice — who do your beauty with intelligence!

Dream Doctors