Skin Repair at the Cellular Level: Unlocking the Power of Polynucleotides
- Dr. Amaani
- Jun 6
- 3 min read
In today’s blog article we are going to discuss another evolving injectable which is Polynucleotides. One of the most promising advancements in regenerative aesthetics is polynucleotides (PNs)—a groundbreaking treatment that enhances skin repair, hydration, and collagen production at a cellular level. Among the leading brands in this field are Plinest, Newest, and Plinest One, each offering unique benefits for skin rejuvenation and tissue repair.
What Are Polynucleotides?
Polynucleotides (PN) store and transmit genetic information. PN therapy offers a cutting-edge method that utilizes nucleic acids to activate cellular functions and support the body’s natural healing mechanisms. In aesthetic applications, they work by stimulating tissue regeneration, wound healing, and collagen synthesis at the cellular level.
Unlike hyaluronic acid-based skin boosters that primarily focus on hydration, polynucleotides go a step further by actively repairing and rejuvenating the skin.
Benefits of Polynucleotides in Skin Rejuvenation
Polynucleotides offer multiple skin regeneration benefits that make them a superior choice for long-term skin health:
1. Deep Skin Repair & Regeneration
Polynucleotides stimulate fibroblast activity, which accelerates cell turnover and tissue repair. This makes them highly effective for treating damaged skin, scars, and signs of aging.
2. Long-Lasting Hydration & Elasticity
Unlike hyaluronic acid, which primarily attracts moisture to the skin, polynucleotides improve the skin’s ability to retain hydration at a deeper level. This results in long-term improvements in skin texture and elasticity.
3. Anti-Inflammatory & Antioxidant Properties
Polynucleotides reduce oxidative stress and inflammation, making them beneficial for sensitive, rosacea-prone, or acne-prone skin. They also help prevent premature aging caused by environmental damage.
4. Collagen & Elastin Stimulation
By boosting fibroblast activity, polynucleotides increase collagen and elastin production, leading to firmer, plumper skin. This helps in reducing fine lines, wrinkles, and sagging.
5. Safe & Biocompatible
Since polynucleotides are derived from purified DNA, they are biocompatible and safe with minimal risk of allergic reactions. They are also non-toxic and non-immunogenic, making them suitable for most skin types.
Plinest, Newest, and Plinest One: What’s the Difference?
1. Plinest
Plinest is designed for deep skin rejuvenation and repair. It is known for:
Strong fibroblast stimulation → Increased collagen and elastin production
Effective for aging skin → Treats fine lines, wrinkles, and sagging
Deep hydration & antioxidant benefits → Improves overall skin health
Plinest is ideal for patients seeking comprehensive skin rejuvenation with long-term results.
2. Newest
Newest combines 3 unique ingredients, polynucleotide (PN), hyaluronic acid (HA), and mannitol which works synergistically to help you look and feel your confident best.
The addition of HA promotes hydration and elasticity. Meanwhile, mannitol prolongs the effect of HA for a longer-lasting result.
Newest is a great option for patients with that need both hydration and bio revitalisation.
3. Plinest One
Plinest One is a lighter polynucleotide formulation designed to help :
Reduce the appearance of stretch marks
Lighten & flatten atrophic scars
Promote visible skin firmness and elasticity
Who Is an Ideal Candidate for Polynucleotide Treatment?
Polynucleotide injections are suitable for:
Aging skin with fine lines and wrinkles
Dull, dehydrated skin needing deep hydration
Acne scars and post-inflammatory hyperpigmentation
Sensitive or rosacea-prone skin
What to Expect During & After Treatment
Procedure Overview
The skin is cleansed, and a numbing cream is applied.
Polynucleotides are injected using a fine needle or cannula.
The procedure takes 30-45 minutes, depending on the treatment area.
Post-Treatment Care
Mild redness and swelling may occur but subside within 24-48 hours.
Avoid makeup and excessive sun exposure for 24 hours.
Use gentle skincare and sunscreen to protect the skin.
Most patients notice visible skin improvements within 2-4 weeks, with optimal results after 3 sessions spaced 2-4 weeks apart.
Conclusion
Polynucleotides are revolutionizing skin rejuvenation by addressing skin aging at a cellular level. They not only hydrate but also repair and regenerate skin tissues, making them a superior choice for long-term skin health.
If you’re looking for natural skin restoration with lasting results, polynucleotide therapy might be the perfect solution.
Book an appointment at Dream Clinic today and discover the power of regenerative skin treatments!
References
PLINEST | Ardence Pharma SDN BhD. (n.d.). Ardence Pharma Sdn Bhd. https://www.ardencepharma.com/plinest-2/
NEWEST | Ardence Pharma SDN BhD. (n.d.). Ardence Pharma Sdn Bhd. https://www.ardencepharma.com/newest-2/
Lee, K. W. A., Chan, K. W. L., Lee, A., Lee, C. H., Wan, J., Wong, S., & Yi, K. (n.d.). Polynucleotides in Aesthetic Medicine: A review of current practices and Perceived effectiveness. International Journal of Molecular Sciences. https://pmc.ncbi.nlm.nih.gov/articles/PMC11311621
