Profhilo vs Rejuran: Which Skin Booster Is Right for You?
- Dream Clinic
- Feb 28
- 6 min read
Both are skin boosters, but they don’t work the same.
If you’re thinking of getting skin boosters, chances are you’ve come across Profhilo and Rejuran more than once.
They’re often mentioned in the same breath, recommended for “skin quality,” and sometimes even treated as interchangeable options. That’s where the confusion begins.
In reality, Profhilo and Rejuran are designed to solve different skin problems, through very different biological mechanisms.
Choosing the wrong one won’t harm you, but it may leave you underwhelmed, uncomfortable, or questioning whether injectables are “worth it” at all. The right skin booster should fit your skin, lifestyle, downtime tolerance, and long-term goals.
This article breaks down Profhilo and Rejuran in a clear, practical comparison, so you can decide confidently.
Understanding Skin Boosters: Why Profhilo & Rejuran Are Not Interchangeable
Skin boosters are injectable treatments designed to improve skin quality rather than facial shape. Unlike dermal fillers that add volume or alter contours, skin boosters work within the skin to improve hydration, elasticity, texture, and overall health.
Advanced injectables go beyond skincare because:
Topical products cannot penetrate deeply enough to stimulate collagen effectively
Ageing skin requires structural support and regeneration, not just moisture
Environmental stress, long working hours, and inflammation accelerate skin decline internally
This is where Profhilo and Rejuran come in, but they approach the problem from entirely different angles.
Profhilo is hyaluronic-acid (HA) based, focusing on hydration, elasticity, and skin remodelling
Rejuran is polynucleotide (PN) based, focusing on skin repair, regeneration, and healing
Looking to achieve a fuller, youthful appearance? Explore our article on anti-aging treatments where we go in-depth into laser treatments, skin lifting procedures, and more!
Profhilo: For Hydration, Lifting & Overall Skin Quality
What It Is: The Remodeler
Profhilo is a high-concentration hyaluronic acid injectable designed to remodel ageing skin. Unlike traditional fillers, it spreads evenly under the skin rather than sitting in one place, improving skin quality globally.
How It Works
Profhilo works by:
Delivering intense hydration deep into the skin
Stimulating collagen and elastin production
Improving skin laxity and elasticity over time
Its unique formulation allows it to flow freely, supporting skin from within rather than creating volume.
Best For
Profhilo is ideal for:
Dry, crepey, or dull skin
Mild to moderate sagging, especially in the mid-face and jawline
Neck ageing and loss of firmness
Senior working professionals who want visible improvement with minimal downtime
Rejuran: For Skin Repair & Texture Refinement
What It Is: The Healer
Rejuran is made from polynucleotides (PN) derived from salmon DNA. These molecules are biocompatible with human skin and are used to repair and regenerate damaged tissue at a cellular level. Rejuran also contains hyaluronic acid at a lower concentration to support skin hydration and overall skin quality.
How It Works
Rejuran focuses on healing rather than hydration. It:
Repairs damaged skin cells
Improves skin barrier function
Stimulates collagen regeneration
Refines pores, texture, and acne scars
Because of its thicker consistency and regenerative focus, Rejuran works deeper and more gradually.
Best For
Rejuran is better suited for:
Thinner, weakened, or sensitised skin
Acne scars and uneven texture
Enlarged pores
Patients willing to accept mild downtime for long-term skin repair
Curious how Rejuran measures up to other skin booster treatments? Check out our article on Plinest Treatment, where we compare the key features of both treatments.
Profhilo vs Rejuran: Side-by-Side Comparison
Here’s a quick side-by-side to help you decide:
Factor | Profhilo | Rejuran |
Key Ingredient | Hyaluronic Acid (HA) | Polynucleotides (PN) |
Best Skin Concern | Hydration, laxity, overall skin quality | Skin repair, texture, acne scarring |
Downtime | Minimal (usually 24 hours) | Mild (small bumps may last a few days) |
Number of Sessions | Typically 2 sessions | Usually 3-4 sessions |
Results Onset | Visible glow and firmness within weeks | Gradual improvement over multiple sessions |
Longevity | 6-9 months | Results build progressively and can last longer with maintenance |
Pain Level | Mild to moderate | More discomfort due to viscosity (source) |
The Reality of Pain & Risks: What You Must Know
Managing the “Ouch” Factor
Between the two, Rejuran is consistently reported to cause more discomfort due to its thicker viscosity (source). To manage discomfort, clinics often use:
Extended numbing times
Icing
Vibration tools during injection
Profhilo, on the other hand, tends to feel less stingy and more like pressure under the skin, making it more tolerable for pain-sensitive patients.
The “Seafood Check” for Rejuran
Because Rejuran is derived from salmon DNA, there is a theoretical risk for individuals with severe fish or seafood allergies (source).
While the DNA is highly purified and protein-free, removing most allergens, patients with a history of anaphylaxis to seafood should:
Disclose their allergy clearly
Consider a patch test
Undergo a detailed consultation before treatment
Additionally, a small percentage of patients with congested skin may experience a temporary “purge” (minor acne flare-ups) as Rejuran accelerates cell turnover (source). This is not an allergic reaction but a sign of increased skin renewal.
The “Bumpy” Phase for Profhilo
Profhilo flows freely under the skin, which means:
The risk of permanent lumps is low
However, if injected too superficially, visible blebs may remain for longer than 24 hours
Bruising is the most common side effect. Patients are usually advised to avoid alcohol, fish oil, and blood-thinning supplements for at least three days before treatment to minimise this risk.
Why Profhilo Is Often the More Convenient Choice
For many senior professionals, Profhilo is considered a better alternative to Rejuran because:
It is significantly less discomfort
Downtime is minimal
Treatment protocols are simpler
It typically requires only two sessions, compared to Rejuran’s three to four (source)
This makes Profhilo especially attractive for those who want visible improvement without repeated appointments or recovery days.
Who Should Skip These Treatments?
Who Should Avoid Rejuran
Pregnant or breastfeeding women (standard medical precaution)
Anyone allergic to fish products or any component of the formulation
Individuals with hypersensitive or very thin skin
Who Should Avoid Profhilo
Pregnant or breastfeeding women
Anyone with hypersensitivity to hyaluronic acid
Anyone with active infection or inflammation near the treatment area
Find the Right Booster For You at Dream Clinic
Profhilo and Rejuran aren’t competitors, they’re designed to solve different skin concerns.
If you’re looking for better hydration, improved firmness, and a refreshed appearance that fits a busy professional lifestyle, Profhilo is often the more convenient choice.
If your concern lies with damaged skin, uneven texture, or acne scarring, and you’re comfortable with additional sessions and mild downtime: Rejuran may offer deeper skin repair.
The best results come from choosing a treatment that matches your skin condition, tolerance, and lifestyle.
A personalised consultation at Dream Clinic ensures you receive the right recommendation, so you can move forward with clarity and confidence.
At Dream Clinic, we’re committed to providing the best care for beauty seekers. Our team delivers exceptional services and the highest regards of safety in the latest premium medical aesthetic treatments such as Profhilo and Rejuran.
Recognised as one of the Top 3 Aesthetic Clinics in Penang, our reputation extends across Malaysia and the wider region, including KL, Johor, Borneo, Indonesia, and Singapore.
Moreover, we’ve been recognised as a Rejuran Authorized Injector by Rejuran and Pharma Research; and we’ve received the Certificate of Excellence (Rejuran Authorized Injector) from Pharma Research and Elogia.
FAQs
Q1. Can I do Profhilo and Rejuran together?
Yes, they can be combined, but not usually in the same session. Most doctors stagger the treatments to address hydration and lifting first (Profhilo), followed by skin repair and texture refinement (Rejuran).
Q2. Can sensitive skin handle these treatments?
Sensitive skin can tolerate Profhilo well due to its simple hyaluronic acid formulation. Rejuran may be suitable in selected cases but requires careful assessment, as it can be more stimulating to reactive or thin skin.
Q3. Can I wear makeup immediately after?
It’s best to avoid makeup for at least 24 hours to reduce the risk of irritation or infection. If necessary, light mineral makeup may be allowed after your doctor confirms the injection points have settled.
Q4. Can I treat my neck and hands?
Yes, both Profhilo and Rejuran can be used on the neck, while Profhilo is commonly used on the hands for hydration and skin quality improvement. Rejuran on the hands is less common and usually reserved for texture or skin damage concerns.
Q5. Is Profhilo or Rejuran better for menopausal skin?
Profhilo is often preferred for menopausal skin because it addresses dehydration, laxity, and loss of elasticity caused by hormonal changes. Rejuran may be added later if there are concerns about thinning skin or poor texture.
Q6. Do I need to continue these treatments forever?
No, but maintenance is recommended as skin continues to age naturally. Most patients choose top-up sessions every 6–12 months to maintain results rather than repeating full treatment courses.
References
1. Cassuto, D., Cigni, C., Bellia, G., & Schiraldi, C. (2023). Restoring Adipose Tissue Homeostasis in Response to Aging: Initial Clinical Experience with Profhilo Structura®. Gels, 9(8), 614. https://doi.org/10.3390/gels9080614
2. Choi, S. Y., Koh, Y. G., Yoo, K. H., Han, H. S., Seok, J., & Kim, B. J. (2025). A Randomized, Participant‐and Evaluator‐Blinded, Matched‐Pair, Prospective Study Comparing the Safety and Efficacy Between Polycaprolactone and Polynucleotide Fillers in the Correction of Crow's Feet. Journal of Cosmetic Dermatology, 24(1), e16576. https://doi.org/10.1111/jocd.16576
3. Kim, J. S., & Atchima, S. (2025). Analysis of Dermal Thickness Across 10 Areas and Injection Depth After Polynucleotide Injection Using Rejumate Automatic 0.8-mm 9-pin Injector on the Face Using 33-MHz Sonography. Plastic and Reconstructive Surgery–Global Open, 13(9), e7121. https://pubmed.ncbi.nlm.nih.gov/41000432/
4. March, B. (2024, March 18). Profhilo and other injectable “skin boosters” explained. Harper’s BAZAAR. https://www.harpersbazaar.com/uk/beauty/skincare/a29759932/profhilo/
5. Wu, S. Y. (2024, October 30). I Flew to Seoul to Try Salmon Sperm Injections for My Skin. Marie Claire. https://www.marieclaire.com/rejuran-salmon-sperm-injections-korean-skincare-review/
