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Writer's pictureDr. Vera Teh

Polynucleotide (PN): The Game-Changer of Regenerative Medicine

Updated: 6 days ago

Polynucleotide (PN) therapy has emerged as a promising avenue in the field of regenerative medicine, offering new possibilities for tissue repair and regeneration. Though PN therapy might sound like a mouthful, don't worry, it's not as intimidating as it sounds. In simple terms, it involves using a type of molecule called polynucleotides (PN) to promote tissue regeneration and healing in the body. Think of it as giving your cells a pep talk and encouraging them to get their act together for some serious repair work.


Now, ready to dive into the magic of PN and discover why they're revolutionising skincare and anti-aging treatments?



What is Polynucleotide (PN)?


What is Polynucleotide?

PN are the unsung heroes of our cellular DNA. These long chains of nucleotides—think of them as the building blocks of life—store and transmit genetic information. This innovative approach of PN therapy harnesses the power of nucleic acids to stimulate cellular processes and enhance the body's natural ability to heal. When harnessed in aesthetic treatments, PNs work wonders at the cellular level, promoting healing, boosting collagen production, and revitalizing your skin from within.


Polynucleotide therapy isn't just a cool new kid on the block – it has a history. Scientists have been tinkering with these molecules for a while now, exploring their potential in regenerative medicine. As research advances, we're unlocking more of their secrets and finding new ways to harness their power for the greater good of our tissues.



How does it work? 


When it comes to regenerative medicine, understanding how things work on a cellular level is key. Let's dive into the inner workings of PN therapy and how it does its magic.



Cellular Signalling Pathways


Picture this: polynucleotides waltzing into your cells and whispering sweet nothings to activate specific cellular pathways. These signals tell the cells to get into gear, promoting growth, repair, and regeneration like a conductor leading a symphony of healing.



Tissue Repair and Regeneration Processes


From repairing damaged bones to rejuvenating aged skin, polynucleotide therapy targets different tissues with the precision of a skilled craftsman. By stimulating the body's natural repair mechanisms, these molecules help tissues bounce back from injury or ageing, giving them a new lease on life.



The General Benefits of Polynucleotide


1. Cellular Regeneration: PNs jumpstart the body's natural healing process, encouraging cell growth and tissue repair.

2. Anti-Inflammatory Properties: They soothe irritated skin, reducing redness and swelling.

3. Enhanced Elasticity: By stimulating collagen production, PNs improve skin elasticity, smoothing out fine lines and wrinkles.




Is that all? You’re missing some big pictures.


1. Scar Resurfacing: PNs accelerate the formation of new skin cells, effectively minimising the appearance of scars.


2. Pore Minimising: They refine and tighten skin, reducing pore size for a smoother complexion.


3. Texture Improvement: Regular PN treatments even out skin texture, giving you a silky, radiant finish.


4. Erythema Control: Their anti-inflammatory action calms redness, providing a more even skin tone.


5. Strengthening Skin Barrier: PNs bolster the skin’s natural barrier, defending against environmental damage and pollutants.



Targeted Treatments for Every Area


Polynucleotides aren’t just for your face—they’re a versatile solution for various parts of your body:


1. Eyes: Banish fine lines, crow's feet, and dark circles, rejuvenating the delicate skin around your eyes.


2. Body: Improve skin firmness and texture in areas like the neck, décolletage, hands, abdomen; you name it. 


3. Private Areas: Keen to boost intimate well-being? PN helps to enhance tissue repair and hydration for sensitive areas, promoting overall skin health.


4. Hair: Ya, don’t be surprised. That includes your brow and beard, cool ain’t it? Primarily targeting the scalp’s health at a cellular level to foster an environment where hair can thrive, it boosts the natural thickness and volume of our hair. 



Spotlight on Plinest and Rejuran Series PN


Among the star players in PN treatments are the Plinest and Rejuran series, both renowned for their high concentrations of polynucleotides. These series excel in deep regeneration, intense hydration, boosting skin elasticity, repairing damaged skin, diminishing fine lines, and enhancing overall skin texture and tone. They are particularly effective for scar reduction and pore minimization, making them complementary powerhouses in the world of skin rejuvenation.

Rejuran

(https://www.elogioasia.com/product/filler/rejuran/)


(https://www.ardencepharma.com/plinest-2/)



Integrating PNs into Your Anti-Aging Routine


Polynucleotides are more than just a standalone treatment—they’re a crucial part of a comprehensive anti-aging regimen. Here’s how they fit in:


- Skin Rejuvenation: PNs are used to rejuvenate the skin, working alongside fillers that targets on restoring the deeper structures like bones and energy-based devices (primarily strengthens and tightens the SMAS layer) to provide a holistic approach to anti-aging.


- Synergy effect : By combining PN treatments with other anti-aging solutions, such as hydrators, RH collagen, peptides and many more, you can achieve synergy benefits, addressing all skin concerns at once. 



The Creative Frontier of Polynucleotide Treatments


Polynucleotides open up a world of possibilities in skincare and beyond. Whether you’re targeting fine lines around the eyes, refining your skin’s texture, or tackling specific issues like scars and redness, PNs truly are the game face of regenerative medicine, providing comprehensive solutions and redefining the standards of beauty and skin health.


Step into the future of skincare with PN treatments at Dream Clinic and embrace a younger, healthier, and more radiant you. Your skin deserves the best and nothing can hold you back! 




References


Cavallini, M. et al. (2020) ‘Consensus report on the use of PN‐HPTTM (polynucleotides highly purified technology) in Aesthetic Medicine’, Journal of Cosmetic Dermatology, 20(3), pp. 922–928. doi:10.1111/jocd.13679. 


Lee, D. et al. (2023) ‘Current practices and perceived effectiveness of polynucleotides for treatment of facial erythema by cosmetic physicians’, Skin Research and Technology, 29(9). doi:10.1111/srt.13466. 


Lim, T. S. et al. (2024) ‘Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation’, Clinical, Cosmetic and Investigational Dermatology, 17, pp. 417–431. doi: 10.2147/CCID.S437942.


Pak, C.S. et al. (2014) ‘A phase III, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare the durability, efficacy and safety between polynucleotide filler and hyaluronic acid filler in the correction of Crow’s feet: A new concept of Regenerative Filler’, Journal of Korean Medical Science, 29(Suppl 3). doi:10.3346/jkms.2014.29.s3.s201. 


Rho, N.K. et al. (2023) ‘A survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean dermatologists’, Journal of Cosmetic Dermatology, 23(4), pp. 1243–1252. doi:10.1111/jocd.16125. 



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