Polynucleotide (PN): The Game-Changer of Regenerative Medicine

Polynucleotide (PN) therapy is making waves in regenerative medicine, opening up exciting possibilities for tissue repair and healing. While it might sound technical, don’t worry—it’s not as complicated as it seems.

In simple terms, PN therapy uses special molecules called polynucleotides to help your body heal and regenerate tissue. Think of them as giving your cells a pep talk and encouraging them to get their act together for some serious repair work.

So, what’s the magic behind PN therapy? Let’s dive in together.

What is Polynucleotide (PN)?

Polynucleotides are long chains of nucleotides—aka the building blocks of DNA. They play a key role in storing and transmitting genetic information. By tapping into the power of these molecules, PN therapy stimulates your body’s natural healing processes, making it a game-changer in skincare and anti-aging treatments.

When used in aesthetic treatments, PNs work at a deep cellular level. They promote tissue repair, boost collagen production, and help revitalize your skin from the inside out—leaving you with a healthier, more radiant appearance.

But PN therapy isn’t just a trendy new option. Researchers have been studying these molecules for years, uncovering their potential in various medical fields. As science continues to evolve, we’re learning even more about how to use polynucleotides to support healing and regeneration across the body.

What Makes Polynucleotides Particularly Noteworthy Is Their Biocompatibility

Unlike synthetic compounds that may trigger adverse reactions, polynucleotides are recognized by the human body as natural substances, significantly reducing the risk of rejection or inflammatory responses. This intrinsic compatibility allows PNs to integrate seamlessly with the body’s own regenerative mechanisms.

In aesthetic and medical applications, purified polynucleotide formulations are precisely delivered to target tissues through minimally invasive injection techniques. These specialized preparations contain a concentrated matrix of nucleic acids that serve as biological messengers, initiating a cascade of regenerative processes at the cellular level.

How Does Polynucleotide Treatment Work?

As we age, our bodies naturally slow down the production of collagen and elastin—the proteins responsible for keeping our skin firm, plump, and elastic. This leads to visible signs of aging like sagging, fine lines, and dullness. That’s where polynucleotide therapy steps in, acting like a gentle nudge to your skin, reminding it to get back to work.

Cellular Signalling Pathways

Polynucleotides work by reactivating these fibroblasts. Once injected into the skin, the DNA fragments are gradually absorbed and begin to send signals to your skin cells. These signals do 3 important things:

Stimulate Fibroblast Proliferation: Polynucleotides "wake up" fibroblasts, encouraging them to multiply and ramp up their activity. This helps restore their ability to produce collagen and elastin—key components for youthful, resilient skin.

Act as Antioxidants: They neutralize free radicals, protecting your cells from oxidative stress and reducing inflammation. This is especially important for preventing further aging and maintaining healthy skin over time.

Initiate Cellular Repair Messaging: Polynucleotides signal the skin to enter a regenerative mode, encouraging DNA repair and increasing cellular turnover. This process not only improves the overall function of the skin but also enhances its natural radiance.

Tissue Repair and Regeneration Processes

Once the signalling process is in motion, your skin begins to heal and regenerate more effectively. Here’s how that plays out visibly and functionally:

Enhanced Collagen & Elastin Production: With fibroblasts reactivated, your skin starts producing more collagen and elastin—restoring firmness, improving elasticity, and reducing the appearance of wrinkles.

Improved Hydration: Polynucleotides have an innate ability to retain moisture, helping your skin stay deeply hydrated. This doesn’t just enhance skin comfort—it also boosts suppleness and glow.

Boosted Cellular Turnover: By accelerating the renewal of skin cells, PN therapy refines skin texture, evens out tone, and reduces the appearance of scars, stretch marks, and pigmentation.

Wound Healing & Skin Repair: Whether you’re dealing with sun damage, acne scars, or general skin fatigue, polynucleotides support intensive tissue regeneration. This includes better blood flow, improved nutrient delivery, and repair of damaged or aging skin.

Mild Volume and Tightening Effects: Some users notice a subtle increase in volume and skin tightening, thanks to the combined impact of improved hydration and collagen density.

It’s important to understand that PN therapy works gradually rather than instantly. The healing processes unfold over several weeks as your body’s natural regenerative abilities are enhanced. This approach leads to improvements that look natural and continue to get better over time as your body does the work.

You might already know that both Hyaluronic Acid Fillers and Polynucleotide Therapy are popular choices for skin hydration and rejuvenation. But you may be wondering—which one is right for you? Feel free to explore the key differences between HA Filler and PN Therapy and find out which treatment might suit your skin needs best!

The General Benefits of Polynucleotide Treatment

Polynucleotide therapy offers a comprehensive range of benefits that address multiple aspects of tissue health and function. Its holistic approach to regeneration makes it a versatile option for various aesthetic and medical applications.

Cellular Regeneration

PNs fundamentally rejuvenate tissues by accelerating cell renewal and optimizing cellular function. This regenerative capability is particularly valuable for addressing age-related tissue deterioration.

Anti-Inflammatory Properties

PNs modulate inflammatory responses through specific receptor interactions, reducing inflammation and promoting a balanced immune environment conducive to healing.

Enhanced Elasticity

By stimulating the production of elastin fibers and improving the overall extracellular matrix composition, PN treatments significantly improve tissue elasticity and resilience.

Superior Hydration

The hygroscopic properties of polynucleotides, coupled with their ability to enhance hyaluronic acid synthesis, create deep and lasting tissue hydration that surpasses many conventional treatments.

Natural Biorevitalization

Rather than simply masking imperfections, polynucleotides initiate true biological renewal, resulting in authentic tissue improvement that maintains natural expressiveness and function.

Is that all? You’re missing some big pictures.

While the fundamental benefits of polynucleotide therapy are impressive, its full potential extends well beyond these primary effects. Consider these additional advantages that highlight the comprehensive nature of PN treatments:

Scar Resurfacing

PNs demonstrate remarkable efficacy in remodeling scar tissue by normalizing collagen fiber orientation and improving tissue architecture. This makes them valuable for addressing both recent and mature scars.

Pore Minimizing

The improvement in dermal structure and enhanced skin surface tension achieved with PN therapy leads to noticeable refinement of enlarged pores, creating a smoother, more even complexion.

Texture Improvement

Beyond general skin quality enhancement, PNs specifically target micro-irregularities in tissue texture, resulting in a silky, uniform finish that reflects light more evenly.

Erythema Control

The anti-inflammatory action of PNs makes them particularly effective for managing persistent erythema (redness) associated with conditions like rosacea or post-procedural inflammation.

Strengthening Skin Barrier

PNs reinforce the skin’s natural protective barrier by optimizing lipid composition and enhancing cellular cohesion in the stratum corneum. This improved barrier function protects against environmental aggressors and prevents transepidermal water loss.

Targeted Treatments for Every Area

Polynucleotides aren’t just for your face—they’re a versatile solution for various parts of your body:

1. Eyes: Banish fine lines, crow's feet, and dark circles, rejuvenating the delicate skin around your eyes.

2. Body: Improve skin firmness and texture in areas like the neck, décolletage, hands, abdomen; you name it.

3. Private Areas: Keen to boost intimate well-being? PN helps to enhance tissue repair and hydration for sensitive areas, promoting overall skin health.

4. Hair: Ya, don’t be surprised. That includes your brow and beard, cool ain’t it? Primarily targeting the scalp’s health at a cellular level to foster an environment where hair can thrive, it boosts the natural thickness and volume of our hair.

Each application area benefits from customized protocols considering factors such as tissue characteristics, depth of injection, concentration of polynucleotides, and treatment intervals. This targeted approach maximizes results while ensuring safety and comfort for each specific region.

What Makes Polynucleotides So Skin-Friendly?

The exceptional compatibility of polynucleotides with human tissues stems from several distinct properties that set them apart from other aesthetic injectables:

1. Biomimetic Structure: Polynucleotides closely resemble the body’s own nucleic acid structures, allowing them to integrate with natural physiological processes rather than disrupting them.

2. Non-Antigenic Profile: The purification processes used in pharmaceutical-grade PN preparations remove potentially antigenic components, resulting in a remarkably low risk of immunological reactions.

3. Physiological Degradation: Unlike synthetic compounds that may leave residual by-products, polynucleotides are metabolized through natural pathways, breaking down into components that the body can readily process and eliminate.

4. Cellular Affinity: The molecular structure of polynucleotides enables specific interactions with cell surface receptors, facilitating targeted biological effects without unwanted systemic impacts.

5. Environmental Resilience: Polynucleotides demonstrate stability in varying tissue environments, maintaining their therapeutic activity across different pH levels and oxygen tensions found in diverse tissue types.

6. Thermal Stability: The structural properties of polynucleotides allow them to withstand temperature variations without denaturing, contributing to their reliable performance in vivo.

7. Absence of Inflammatory Triggers: Unlike some dermal fillers or biostimulators, polynucleotides do not induce the pro-inflammatory cascades that can lead to post-treatment discomfort or prolonged recovery periods.

These skin-friendly characteristics explain why polynucleotide treatments typically result in minimal downtime, with patients often able to resume normal activities immediately following treatment sessions.

Curious about what medical grade treatments—besides Polynucleotide Therapy—can give your skin that smooth, glassy glow? We've rounded up all the advanced solutions available at Dream Clinic just for you!

Spotlight on Plinest and Rejuran Series PN

Among the standout names in PN treatments are the Plinest and Rejuran series, both known for their high concentrations of polynucleotides. These treatments are designed to deliver deep skin regeneration and intense hydration, while also enhancing elasticity and repairing damaged skin.

They help reduce fine lines, improve overall skin texture and tone, and are especially effective for minimizing pores and fading scars. Together, Plinest and Rejuran are powerful allies in the pursuit of smoother, healthier, and more youthful-looking skin.

(https://www.elogioasia.com/product/filler/rejuran/)

Rejuran Series

The Rejuran line offers innovative polynucleotide complexes engineered for specific regenerative outcomes:

Proprietary PDRN Technology: Contains standardized polynucleotide fragments with optimal bioactivity
Specialized Applications: Different formulations tailored for facial rejuvenation, body treatments, and hair restoration
Healer Model: Focuses on fundamental tissue repair mechanisms rather than temporary cosmetic enhancement
Progressive Results: Delivers continuing improvement over months as biological processes advance
Complementary Integration: Designed to work synergistically with other aesthetic treatments for enhanced outcomes

(https://www.ardencepharma.com/plinest-2/)

Plinest Series

The Plinest formulations incorporate highly purified polynucleotide fractions specifically calibrated for deep tissue regeneration. Key features include:

Precision Formulation: Standardized molecular weight distribution optimized for maximum biological activity
Comprehensive Protocol: Systematic treatment approach with specified intervals for progressive improvement
Targeted Variants: Specialized formulations for different anatomical regions and tissue concerns
Enhanced Stability: Advanced stabilization techniques for preserved bioactivity and extended shelf life
Documented Efficacy: Extensive clinical studies demonstrating significant improvements in tissue parameters

Both series share the fundamental regenerative mechanism of polynucleotides while offering distinctive approaches to tissue revitalization. The selection between these premium options typically depends on specific patient characteristics, treatment goals, and the practitioner’s clinical experience.

Integrating PNs Into Your Anti-Aging Routine

Polynucleotides represent not merely a standalone treatment but a foundational component of a comprehensive anti-aging strategy. Their ability to optimize tissue biology makes them ideal complements to various other interventions:

Skin Rejuvenation

Polynucleotides (PNs) have become a cornerstone of modern skin rejuvenation strategies. Unlike traditional treatments that focus solely on surface-level improvements, PNs work deep within the skin to stimulate cellular repair and regeneration.

When used alongside dermal fillers, which help restore volume and support underlying structures like bone, and energy-based devices that target and tighten the SMAS layer (the deeper connective tissue layer of the face), PN treatments contribute to a comprehensive, multi-layered anti-aging approach.

This synergistic method not only addresses wrinkles and sagging, but also enhances skin health at the cellular level—promoting long-term improvements in elasticity, hydration, and overall texture. The result is a more youthful, lifted, and naturally refreshed appearance from the inside out.

Synergy Effect with Other Anti-Aging Solutions

One of the greatest strengths of PN therapy lies in its compatibility with other advanced skincare treatments. When combined with hydrators, RH (recombinant human) collagen, peptides, antioxidants, and growth factors, PNs amplify the effectiveness of each component—creating a powerful synergy that targets multiple skin concerns in one protocol.

This integrative approach allows practitioners to customize treatment plans based on each individual’s skin needs, whether it’s fine lines, dullness, dehydration, pigmentation, or loss of firmness. By layering complementary treatments, patients can experience faster recovery, longer-lasting results, and more visible improvements in tone, texture, and radiance.

The Creative Frontier of Polynucleotide Treatments

At Dream Clinic, we’ve seen how polynucleotide therapy has truly redefined what’s possible in skin rejuvenation. What excites us most is that this treatment doesn’t just offer surface-level improvements—it works deep within the skin to activate real, lasting regeneration. It’s not about covering up flaws; it’s about restoring your skin’s natural vitality from the inside out.

When patients ask us what sets polynucleotides apart, we explain it simply: we’re giving your skin the building blocks and signals it needs to heal itself. It’s a gentle yet powerful way to encourage your body to do what it was designed to do—repair, renew, and glow.

The results speak volumes. Our patients often share that their skin doesn’t just look better—it feels healthier, stronger, and more alive. Friends notice a change but can’t quite put their finger on it—that subtle, natural beauty that comes from within.

Curious about how PN treatments can fit into your skincare journey? Schedule a consultation with our Aesthetic Specialists today. As one of the trusted Skin Clinics in KL and Penang, Dream Clinic is here to guide you with expert care and tailored solutions—so you can look and feel your best, naturally.

References

Cavallini, M. et al. (2020) ‘Consensus report on the use of PN‐HPTTM (polynucleotides highly purified technology) in Aesthetic Medicine’, Journal of Cosmetic Dermatology, 20(3), pp. 922–928. doi:10.1111/jocd.13679.

Lee, D. et al. (2023) ‘Current practices and perceived effectiveness of polynucleotides for treatment of facial erythema by cosmetic physicians’, Skin Research and Technology, 29(9). doi:10.1111/srt.13466.

Lim, T. S. et al. (2024) ‘Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation’, Clinical, Cosmetic and Investigational Dermatology, 17, pp. 417–431. doi: 10.2147/CCID.S437942.

Pak, C.S. et al. (2014) ‘A phase III, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare the durability, efficacy and safety between polynucleotide filler and hyaluronic acid filler in the correction of Crow’s feet: A new concept of Regenerative Filler’, Journal of Korean Medical Science, 29(Suppl 3). doi:10.3346/jkms.2014.29.s3.s201.

Rho, N.K. et al. (2023) ‘A survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean dermatologists’, Journal of Cosmetic Dermatology, 23(4), pp. 1243–1252. doi:10.1111/jocd.16125.