Plenhyage: The Next Generation Injectable for Skin Repair and Glow

Dr. Amaani
Sep 5
3 min read

A glowing, youthful complexion is something many of us strive for, but achieving it isn't always as simple as using the right serum or moisturiser. Our skin changes with age, lifestyle, stress and environmental factors especially in Malaysia’s tropical climate where sun and humidity play such a big role. Over time, the natural production of collagen and elastin slows down, skin becomes thinner and less elastic, fine lines appear and dullness starts to replace radiance.

Polynucleotide therapy is the new era in regenerative aesthetics. Among the latest and most talked about options is Plenhyage, a medical grade polynucleotide designed to improve skin quality, texture, and resilience in a natural and progressive way.

If you’ve been hearing the buzz about polynucleotide (PN) skin treatments and wondering what makes Plenhyage different, this guide is for you. Let me walk you through what it is, how it works, who it’s for, and what to expect.

What is Plenhyage?

Polynucleotides are complex molecules composed of nucleotides, which are the building blocks of DNA and RNA. They have been shown to play a crucial role in various cellular processes, including cell proliferation, differentiation, and survival. Polynucleotides help your skin repair, rebuild, and rehydrate itself over time.

Plenhyage is a medical grade polynucleotide composed of highly purified wild salmon sperm DNA that minimizes immunological side effects.

Plenhyage vs Hyaluronic Acid Skinboosters

Polynucleotides like Plenhyage: Primarily for regeneration and dermal restructuring; supports collagen/elastin synthesis, improves skin architecture over weeks.
HA Skinboosters (e.g., pure hyaluronic acid): Hydration and plumping; immediate dewy effect with water-binding capacity; less direct remodeling signal compared to PN.

Can they be combined? Yes. Often PN + HA skinboosters can produce synergistic results.

Who is Plenhyage best for?

Ideal candidates are men and women looking to improve overall skin quality.

Consider Plenhyage if you have:

Crepey or thinning skin (face, eyelids, neck).
Fine lines especially early periorbital/perioral lines.
Dullness and loss of elasticity.
Textural concerns, including mild acne scarring and enlarged pores.
Sensitive, easily reactive skin that struggles with barrier resilience.
Photoaged skin from sun exposure.

What results can you expect?

Immediately: Mild redness/bumps that settle in hours to a couple of days.
1–2 weeks: Early glow and improved hydration.
6–12 weeks: Progressive improvement in texture, elasticity, and fine lines, especially after the second/third session.

Treatment Plan & Downtime

Number of sessions: Typically 2–4 sessions, spaced 3–4 weeks apart
Each session Takes around 30 minutes
Downtime: Minimal — most clients return to normal activities immediately

Is Plenhyage right for you?

Skin health is more than just what we see on the surface. It's about how well our skin cells regenerate, repair and protect us everyday. Plenhyage goes deeper, targeting the root of skin ageing and skin problems at a cellular level. It is a scientifically grounded, regenerative skin treatment that helps your skin behave more like its younger self, steadily improving texture, elasticity, brightness, and resilience. It doesn’t change your features, it refines the canvas.

If you want naturally better skin with minimal downtime and you value long-term skin health, Plenhyage is a strong contender, whether on its own or combined with other modalities. Book a personalized consultation at Dream Clinic so we can craft a safe, effective plan for you.

References

Lee, K. W. A., Chan, K. W. L., Lee, A., Lee, C. H., Wan, J., Wong, S., & Yi, K. (2024). Polynucleotides in Aesthetic Medicine: A review of current practices and Perceived effectiveness. International Journal of Molecular Sciences, 25(15), 8224. https://doi.org/10.3390/ijms25158224
Cavallini, M., Bartoletti, E., Maioli, L., Massirone, A., Palmieri, I. P., Papagni, M., Priori, M., & Trocchi, G. (2020). Consensus report on the use of PN‐HPT^TM (polynucleotides highly purified technology) in aesthetic medicine. Journal of Cosmetic Dermatology, 20(3), 922–928. https://doi.org/10.1111/jocd.13679